ABSTRACT
This workshop will provide health science librarians and information professionals at any level/context with an overview of the best practices in finding and identifying the best scientific evidence during novel public health emergencies. Attendees will be presented with an overview of a best practices statement developed by the Librarian Reserve Corps. Attendees will then apply the recommendations from the best practices statement in designing a plan to respond to real-life case study/information request during a public health emergency. A discussion period will follow on how to apply the best practices in other contexts, environments, and cultures. Attendees will also be invited to share their own experiences and best practices during the discussion session. Through hands-on learning and discussion, librarians and information professionals at any level/context will develop strategies to find and critically appraise the best evidence in any novel public health emergency situation. Introduction: To inform the design of a consumer health strategy for a provincial health library system, the library sought to understand patient challenges and barriers in accessing quality sources of health information. Description: Over a period of three months in the winter of 2020-2021, the library engaged in semi-structured interviews with relevant clinical and corporate stakeholders. Program leads were asked about their role in consumer health information provision and support, and where they saw gaps and opportunities within the organization. Answers were themed and analyzed, and an internal report was produced to guide next steps in developing a consumer health strategy. Outcomes: The environmental scan showed that there are clear challenges and barriers for patients in accessing quality health information. Barriers include the duration of interaction with a healthcare practitioner;the specificity of patient information needs;and the organizational emphasis on a single enterprise-wide patient information resource. More significant challenges include language;lack of health information literacy skills;and low digital literacy among certain populations. Discussion: The environmental scan results provided strong rationale for developing a cohesive consumer health strategy for the library. They highlighted valuable but disjointed resources and programs throughout the organization. A Consumer Health Framework was drafted to guide the library in setting achievable goals and leveraging existing supports. Due to the Covid-19 pandemic it was not possible to engage directly with patients for the initial scan, however consultation with patient advisory groups is now being planned to check and validate the library’s direction.
ABSTRACT
BACKGROUND: Serological assays for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have roles in seroepidemiology, convalescent plasma-testing, antibody durability and vaccine studies. Currently, SARS-CoV-2 serology is performed using serum/plasma collected by venepuncture. Dried blood spot (DBS) testing offers significant advantages as it is minimally invasive, avoids venepuncture with specimens being mailed to the laboratory. METHODS: A pathway utilizing a newborn screening laboratory infrastructure was developed using an enzyme-linked immunosorbent assay to detect IgG antibodies against the receptor-binding domain of the SARS-CoV-2 spike protein in DBS specimens. Paired plasma and DBS specimens from SARS-CoV-2 antibody-positive and -negative subjects and polymerase chain reaction positive subjects were tested. DBS specimen stability, effect of blood volume and punch location were also evaluated. RESULTS: DBS specimens from antibody-negative (n = 85) and -positive (n = 35) subjects and polymerase chain reaction positive subjects (n = 11) had a mean (SD; range) optical density (OD) of 0.14 (0.046; 0.03-0.27), 0.98 (0.41; 0.31-1.64) and 1.12 (0.37; 0.49-1.54), respectively. An action value OD >0.28 correctly assigned all cases. The weighted Deming regression for comparison of the DBS and the plasma assay yielded: y = 0.004041 + 1.005x, r = 0.991, Sy/x 0.171, n = 82. Extraction efficiency of antibodies from DBS specimens was >99%. DBS specimens were stable for at least 28 days at ambient room temperature and humidity. CONCLUSIONS: SARS-CoV-2 IgG receptor-binding domain antibodies can be reliably detected in DBS specimens. DBS serological testing offers lower costs than either point of care or serum/plasma assays that require patient travel, phlebotomy and hospital/clinic resources; the development of a DBS assay may be particularly important for resource poor settings.